The Difference Between Purines and Pyrimidines

The Difference Between Purines and Pyrimidines Purines and pyrimidines are two types of aromatic heterocyclic organic compounds. In other words, they are ring structures (aromatic) that contain nitrogen as well as carbon in the rings (heterocyclic). Both purines and pyrimidines are similar to the chemical structure of the organic molecule pyridine (C5H5N). Pyridine, in turn, is related to benzene (C6H6), except one of the carbon atoms is replaced by a nitrogen atom. Purines and pyrimidines are important molecules in organic chemistry and biochemistry because they are the basis for other molecules (e.g., caffeine, theobromine, theophylline, thiamine) and because they are key components of the nucleic acids dexoyribonucleic acid (DNA) and ribonucleic acid (RNA). Pyrimidines A pyrimidine is an organic ring consisting of six atoms: 4 carbon atoms and 2 nitrogen atoms. The nitrogen atoms are placed in the 1 and 3 positions around the ring. Atoms or groups attached to this ring distinguish pyrimidines, which include cytosine, thymine, uracil, thiamine (vitamin B1), uric acid, and barbituates. Pyrimidines function in DNA and RNA, cell signaling, energy storage (as phosphates),  enzyme regulation, and to make protein and starch. Purines A purine contains a pyrimidine ring fused with an imidazole ring (a five-member ring with two non-adjacent nitrogen atoms). This two-ringed structure has nine atoms forming the ring: 5 carbon atoms and 4 nitrogen atoms. Different purines are distinguished by the atoms or functional groups attached to the rings. Purines are the most widely occurring heterocyclic molecules that contain nitrogen. They are abundant in meat, fish, beans, peas, and grains. Examples of purines include caffeine, xanthine, hypoxanthine, uric acid, theobromine, and the nitrogenous bases adenine and guanine. Purines serve much the same function as pyrimidines in organisms. They are part of DNA and RNA, cell signaling, energy storage, and enzyme regulation. The molecules are used to make starch and proteins. Bonding Between Purines and Pyrimidines While purines and pyrimidines include molecules that are active on their own (as in drugs and vitamins), they also form hydrogen bonds between each other to link the two strands of the DNA double helix and to form complementary molecules between DNA and RNA. In DNA, the purine adenine bonds to the pyrimidine thymine and the purine guanine bonds to the pyrimidine cytosine. In RNA, adenine bonds to uracil and guanine still bonds with cytosine. Approximately equal amounts of purines and pyrimidines are required to form either DNA or RNA. Its worth noting there are exceptions to the classic Watson-Crick base pairs. In both DNA and RNA, other configurations occur, most often involving methylated pyrimidines. These are called wobble pairings. Comparing and Contrasting Purines and Pyrimidines The purines and pyrimidines both consist of heterocyclic rings. Together, the two sets of compounds make up the nitrogenous bases. Yet, there are distinct differences between the molecules. Obviously, because purines consist of two rings rather than one, they have a higher molecular weight. The ring structure also affects the melting points and solubility  of the purified compounds. The human body synthesizes (anabolism) and breaks down (catabolism) the molecules differently. The end product of purine catabolism is uric acid, while the end products of pyrimidine catabolism are ammonia and carbon dioxide. The body does not make the two molecules in the same location, either. Purines are synthesized primarily in the liver, while a variety of tissues make pyrimidines. Here is a summary of the essential facts about purines and pyrimidines: Purine Pyrimidine Structure Double ring (one is a pyrimidine) Single ring Chemical Formula C5H4N4 C4H4N2 Nitrogenous Bases Adenine, guanine Cytosine, uracil, thymine Uses DNA, RNA, vitamins, drugs (e.g., barbituates), energy storage, protein and starch synthesis, cell signaling, enzyme regulation DNA, RNA, drugs (e.g., stimulants), energy storage, protein and starch synthesis, enzyme regulation, cell signaling Melting Point 214 C (417 F) 20 to 22 C (68 to 72 F) Molar Mass 120.115 gmol1 80.088 g mol1 Solubility (Water) 500 g/L Miscible Biosynthesis Liver Various tissues Catabolism Product Uric acid Ammonia and carbon dioxide Sources Carey, Francis A. (2008). Organic Chemistry (6th ed.). Mc Graw Hill. ISBN 0072828374.Guyton, Arthur C. (2006). Textbook of Medical Physiology. Philadelphia, PA: Elsevier. p. 37. ISBN 978-0-7216-0240-0.Joule, John A.; Mills, Keith, eds. (2010). Heterocyclic Chemistry (5th ed.). Oxford: Wiley. ISBN 978-1-405-13300-5.Nelson, David L. and Michael M Cox (2008). Lehninger Principles of Biochemistry (5th ed.). W.H. Freeman and Company. p. 272. ISBN 071677108X.Soukup, Garrett A. (2003). Nucleic Acids: General Properties. eLS. American Cancer Society. doi:10.1038/npg.els.0001335 ISBN 9780470015902.

Adopting a Start-up Mentality for your Books Reedsy

Adopting a Start-up Mentality for your Books Reedsy Adopt A Startup Mentality For Your Books - By Dr. Sean Wise â€Å"I think I’m the only person who has made the authors into Lego people†At the Reedsy blog, we like to bring together the publishing world and the tech world. We think authors can learn a lot from entrepreneurs (and vice-versa), and today’s interview is dedicated to just that.Dr. Sean Wise is a Canadian entrepreneur, investor, mentor and successful author. He just released his latest book, Startup Opportunities, that he co-wrote with Brad Feld. How do two of the most successful startup investors out there go about marketing their book? Sean shares their secrets on how they engage with readers (careful, it involves Lego figures).He also gives his perspective on the changes the publishing industry is undergoing and on a few startups contributing to its disruption.If you want to see him drive through Toronto in a cab, get out, and walk home - all while chatting with us - just play the video, it’s awesome. Else, the transcript is just below! Dr. Sean Wise, it’s great to have you here. You’re a teacher at Ryerson university on entrepreneurship, are a mentor, advisor and investor, and have been involved with startups pretty much all your life, right? Could you give us a bit of background on that?Absolutely! I was born very, very young, and I grew from there. At 13 I had an experience that confirmed to me that I would never make a good employee and I started my first business. I’m now 43 and I have started 5 of my own businesses, but for the most of my working career I’ve been a venture capitalist. So I’ve been an entrepreneur, a ‘funder’, a founder, a mentor, and all of that has been to accomplish one goal: to help entrepreneurs succeed. Help people fail faster, learn quicker, etc. All of my books to date have been around that topic.That’s fantastic. And talking about your books, you wrote your first book and self-published it in 2007, back when digital publishing almo st wasn’t a thing. Why did you choose the self-publishing route?Well, I think you’d call it self-publishing. I had written a column for the Globe and Mail, which is a national newspaper in Canada, and at the end of a two-year run as a columnist on entrepreneurship, they asked if I’d like to wrap all the articles together, put a cover on it, and publish it. So they published it with me. It was â€Å"self-publishing† because we owned 100% of it, but it was edited and pushed out by a newspaper chain, so it was a very unique experience.My second book was bought by a large publisher called Penguin: it was How To Be A Business Super Hero and it combined my love for comic books with my need to help people understand that business isn’t only about money.For my third book, which came out three years ago, I went back to self-publishing. I published it with a magazine called Profit Magazine, and it’s another book about entrepreneurship called Hot or No t. In Canada (like in England) we have a version of that great TV show called Dragon’s Den (it’s now in 27 countries) and I spent 5 seasons working there to help entrepreneurs get the funding they needed to succeed.Now, full circle for my latest book: FG Press is half self-publishing, half traditional publishing. It’s really a startup publishing brand that is trying to figure out what publishing isn’t doing well at all, and what can be done better.Yes, FG Press is one of these actors that shows how exciting the publishing industry is in its current state. What is it that has changed, exactly, and how do you see it moving forwards?Well, I’m not smart enough to talk about what everyone else is talking about, but I know what I am excited about, so I’ll focus on that. For many many years, the publishing industry has been pretty much like the music industry or the film industry: you had these experts; and these experts, whether they were editors or acquisitions people, were in charge of deciding what the world needed. Without an editor’s blessing, you couldn’t have a book: there was no one to publish or distribute it.But like with most things, the internet has had a dramatic effect on the distribution portion of books. Now that books are digital, we know they’re just like Napster was for music: you can send them over email, you can move them digitally, you can read them on your phone, etc. So it’s made distribution a lot easier. Combine that with Amazon’s self-publishing tools, with Goodread’s ability to engage your authors, with Wattpad that can replace your editor with fans, and you really have eliminated the ability of one superstar sitting there and saying â€Å"your book isn’t good enough†.Now, that’s a double-edged sword. Now that there is no longer some expert that you need to tell, there also is no filter, so the biggest problem with publishing today is that anyone can publish. So how do you get past that?Exactly, and I think that’s a question for all forms of content in general, now that we have user-generated content, right?Absolutely. So it’s not a matter of whether my book is good or not, it’s a matter of whether I can get into people’s funnel: â€Å"can I get them to think about my book, can I resonate with them?† as opposed to â€Å"can I get on the shelves at Barnes and Noble?†.And that’s why it’s so important to build a readership before you publish your book. Which is exactly what you’re doing right now with Brad Feld. You’ve co-authored a book with him, Startup Opportunities, and you’re pretty much everywhere around the world talking about that book!Yes, I’m surprised - but happily so - , it looks like we’re going to have a 20-city book tour. We started last week with 5 cities in Canada, and we’re going to move from there ac ross the US, and who knows, if we’re blessed, we’ll even come to Europe!We’re doing that to build a readership and to engage with our users. It’s very similar if you’re aware of The Lean Startup. That book says that before you sink millions and millions of dollars into building a product, check if anyone cares.So before Brad and I got too deep in this book we started talking to readers, startups, just to ask them questions and to really understand what the need was. So we really based this book, Startup Opportunities, on the idea that people should not start stupid startups, that the problem isn’t just â€Å"how to start a company?†.Before we even launched, we had sold 1500 copies. And I can only hope that that continues and that we’re able to find something that resonates with our readers.What kind of out-of-the box marketing have you done for this book that could inspire other non-fiction authors out there?I think I’m the only person who has made the authors into Lego people. So Brad and I have Lego people that will travel with us, and if people want to tweet a picture of us and them, they’ve got to tweet the little Lego people and whoever tweets that and gets the most retweets, will get their own Lego figures, custom-made for them.I’ve never seen anyone make action figures out of authors and I thought that was kind of fun. So that was pretty unusual. The book tour is pretty standard, the Twitter is pretty standard. We did an infographics and a slideshare, too, which are now also pretty standard.Where do you find your inspiration for all this? I think the greatest thing about the transparency the internet allows, is that everyone can learn from everyone. So I wouldn’t want you to think that all these ideas are mine. I’ve stolen them from other successful authors. In fact, as a professor of entrepreneurship I teach that to my students: â€Å"steal with integrity and pr ide everywhere†. I try to give full attribution: I follow Seth Godin and Guy Kawasaki, they’re sort of my â€Å"author idols†, and I try to see what they’re doing and learn.But as far as I know, I am the only person who has a Lego version of Brad Feld and a Lego version of me.And that’s really really cool. It’s actually the mindset that certain authors in publishing are missing: what could I do that would be cool for my readers, or cool in general?I think, people look at Brad Feld and he’s got 5 or 6 bestsellers, he’s a multi-millionaire, a successful venture capitalist; but they don’t realise that his goal is still the same as every other author: to connect with the readers. All of these new tools are just ways to connect, and I think they’re fabulous because they cut out the middle person.I agree. Talking about â€Å"new tools† if you had to find two startups in the publishing industry that you find partic ularly interesting and are going to follow closely, which would they be? I’m a big fan of Goodreads. I know they’re owned by Amazon right now and that makes them not a startup, but I just think connecting your readers with your authors is so important.If I couldn’t choose Goodreads, I might choose Wattpad. They’ve got about 25 million readers and allows authors to put manuscripts up and get feedback. I’m much more interested in what other founders think about my book than what my father thinks about my book. I want to hear directly from them. Amazing authors who have millions of readers are using Wattpad to engage with them and get their books even tighter. So Wattpad would be one.I’m also another big fan of changing business models. So I found Netflix to be nice because it disrupted Blockbuster. And I think what Scribd is doing with comic books, audiobooks and digital books, this â€Å"all you can eat for $9.99†, is going to impact t he business in a disruptive way. I used to buy my comic books every week at the comic book store. And then I evolved into the digital comic book store, called Comixology. Then, I moved from Comixology, when they got bought by Amazon, to directly purchasing from Amazon.Now Scribd comes along, and it has over 100,000 comic books from Marvel, from Image, and all the things that I love, and instead of paying $30 a month in comic book sales, I pay $9,99. So it caters to another demographic. When I was young, for my birthday, I would always ask for some money for the comic book store. But now I don’t need that, I would ask for a subscription to Scribd, for $9.99.These are part of this bigger ecosystem that’s developing and what I think is most interesting is that it’s developing exactly the same. iTunes is the same as Kindle. Netflix is the same as Next Issue for magazines or Oyster for books or Scribd for comic books.So for me, if I look at the next 5 years, which is what I like to invest on - not companies that are amazing today, but companies that will be amazing in 2020 - I ask myself: what is the next revolution going to be? How do we emulate what’s going on in the music business in the book business? How can I increase my tour sales and keep my book sales up? How do I accept to give an album away for free?Brad and I actually discussed whether we should do a â€Å"pay what you can† model. Radiohead did that for music and they made more money than they would have if they had sold at $9.99. Again, I think these things are still in flux, and we live in an unbelievable time, because every industry is changing, and publishing is just slow because it has very big anchor tenants.Thank you so much for these insights, and for your time, Sean. I look forward to reading Startup Opportunities!Follow Dr. Sean Wise and Reedsy on Twitter:  @SeanWise  and @ReedsyHQWhat kind of out-of-the-box marketing have you  done for your book? How do you build your readership? Which publishing startups do you think are going to succeed? Leave us your thoughts, or any question for Sean, in the comments below!

Reaction paper 3 Assignment Example | Topics and Well Written Essays - 500 words

Reaction paper 3 - Assignment Example Thus, showing how Lardo acquires new meaning as a result of the campaign as an exotic consumption item for the local and middle-class consumers (Alison 455). Therefore, the article explains the meaning of the movement in different areas. The entire article emphasizes on the impacts of the Slow Food Movement. In Italy, the movement succeeded in developing cultural space for a new consumer politics kind of performance. The article explains further that the Slow Food resists the easy categorization in any familiar political narratives terms. Though, it is evident that the promotion has penetrated to the politics process heart in societies of liberal democracy. Hence, the article explains the theory behind the food politics. Alison shows how the movement of Slow Food manifestos encourages the cultural diversity idea. The article explains that the movement urges consumers to purchase niche-marketed foods. Though, with the kind of promotional politics, there can be no guarantees of ideological outcomes. It is evident in the article that, the cultural marketing authenticity politics may have been unexpected results for the direct producers. The entire article explains the formation and impact of the European Union. The article explains the contribution of the union and community in making the world a better place in terms of economic fields, peacekeeping and climate changes. Thus, the main objective of the article is to define the European Union and determine its impact on the European nations in terms of development in economy. The article points out some of the factors that promoted economic development by the new community or union. It emphasizes that the political and economic unification of the involved nations paved way for the integrated economy. In addition the common market concept got extended in the mutual trade of the union; thus promoting the economic

Explain how demands translates into capacity management, production Essay

Explain how demands translates into capacity management, production scheduling and materials requirements - Essay Example It drives the detailed material planning and capacity management requirements to fulfill the known or forecasted demand. Demand is the factor that contributes to the planning of the entire production cycle for a particular time of year. The production schedule gives a structure to depict as to how the manufacturing process has to be carried out. It plans out the inventory, capacity and staffing requirements for the company based on the projected demand. Based on demand as one of the inputs production schedule creates an output that is utilized for decision making. These outputs include the amount of products to be produced, the staffing quantities, the cushion required etc. This schedule helps the organizations in synchronizing their operations, in becoming more efficient and improving accuracy of company’s manufacturing. It enables the different departments to plan their course of action accordingly based on the schedule. For instance it allows marketing department to make le gitimate delivery commitments to warehouse and to the customers. Based on this demand the company may decide to utilize its existing capacity fully to meet the requirements. The capacity management is done to effectively make the most of the capacity that exists.

American Pie :: essays research papers

"American Pie" by Don McLean, is a very interesting song. After listening to the lyrics and the song itself, there is a meaning to this song. Each line of the lyrics has a special meaning to what Don McLean wanted to say, but in his own special way. If one was to look at each lyrics one by one, they will be able to find out the big picture of the whole song. It tells a story of Mclean's favorite performers, Buddy HOlly. American Pie was rumoured to be the name of the plane that BUddy Holly died in. In the begining of the song, he starts out saying, "A long, long time ago, I can still remember how that music made me smile. ANd i knew if I had a chance, that i could make those people dance, and maybe they'd be happy for a while." THis line is talking about how when he was a child he listened to great performers of his time and how he could do the same and make other teenagers happy with his song and make them want to dance and be merry. "But February made me shiver, with every paper I'd deliver, bad news on the doorstep. I couldnt take one more step, I can't remember if I cried when i read about his widowed bride. But something touched me deep inside, the day the music died." This line is the day back in February 3, 1959 when Buddy Holly, Ritchie Valens, and The Big Bopper died in a plane crash. As a child, McLean was a paper boy and the news papers that were being passed that day was spreading "bad" news to everyones' doorstep and Buddy Holly's wife was pregnent when he died and later she had a miscarage. That date, was also refered to the "day music died." "Bye bye Miss American Pie, I drove my Chevy to the levee but the levee was dry. Them good ol' boys were drinkin' whiskey and rye, SIgning This'll be the day that i die. THis'll be the day that i die." This is the chorus line. Miss American Pie was someone McLean had dated as a teenager. It was rumoured he was dating a Miss American candidate at the time. It is also refering to saying good by to the plane that had all three performers. The levee refers to a Movie called MIssissippi Burning, which was about three college students registering to vote as black voters, but were killded and dragged to a levee.

Bridewealth and the American Culture

Bridewealth and the American Culture Family and personal assets affect the choices we make in picking the right mate in Western Culture. The ways we view these issues influences are dating practices, and marriage choices. Evolutionary theory predicts certain mannerism that should influence dating. Most of the time evolutionary theory is reflected in mating practices. Mating choices are also affected cross-culturally in other ways like with the Kipsigis and bridewealth. Choices we make for dating and marriage prospects rate differently according to sex and culture. The evolutionary theory predicts that women will value financial prospects higher than men do (Boyd, 2006, 461). Because women have a larger parental investment in a child, they want to be with a mate who will be able to take care of them. In David Buss' research he found that knowing a persons culture rather than gender will indicate preferences except for good financial prospects(Boyd, 2006, 465). For men in Western Culture good financial prospects are lower on their list and good looks is higher. This may be because women who are more attractive to them give the signal that they are less likely to have diseases, and possible based on their body type may be more fertile. Men and women also differ in the preference for the age of their partners. Men tend to date younger women while women date older men. This relates to the evolutionary theory because men’s fertility only slightly decreases with age, while women fertility ends as they reach menopause. It would make sense in evolutionary terms for men to choose women who have the ability to have children and are therefore younger. In actual practice men do choose women that are younger but not all of them are able to have children. â€Å"Older men may desire younger women, but they may also want to find someone who shares their tastes in music, has similar goals in life, and so on† (Boyd, 2006, 462). They may also settle with knowing that they may only be able to date women who are closer to their own age. In Kipsigis culture bridewealth is practiced. Bridewealth is payment giving to the father of the bride from the groom’s father. The payment, tendered in livestock and cash, compensates the bride’s family for the loss of her labor and gives the groom rights to her labor and the children she bears during her marriages† (Boyd, 2006, 468). It is almost like an investment. The more a woman is â€Å"worth† the higher the bridewealth. A woman is also expected to return to her family during the harvest and a higher bridewealth may be paid if the families are too far apart. Higher br idewealth is also paid for women who have had their first menstruation. This also fits in with evolutionary theory that women have a set timeline for having children. As a woman is younger they may be fit to have more children. A plumper woman will fetch a higher the bridewealth as well. Thinness in animals reflects less of ability for children and these views are reflected in the Kipsigis people when they choose women who have more body. In Western culture bridewealth is not common. Typically the bride’s family is expected to pay for much of the wedding reflecting more of a dowry. In both cultures typically the more desirable the woman’s assets are, the better choices of bridewealth or financial prospects. Mating choices and preferences can very from culture to culture. There is one thing that all cultures have in common which is that females prefer a partner with better financial ability. Evolutionary theory favors mating choices that will produce the most amount of fertility. For the Kipsigis this is seen in the healthier plump women and young women who have the ability to have more children. In Western society men rate attractiveness higher than women and often choose younger women as well even if it doesn’t increase fertility. Our mating choices are based on our gender and culture. References Boyd, Robert, & Silk, Joan B. (2006). How Humans Evolved (4th ed. ). New York: W W Norton & Company.

Preveting Teen Suicide - 823 Words

Imagine a girl, 12 years old in her room. She is standing on a chair . She has a rope around her neck which is tied to the ceiling fan. On the count of three she pushes the chair off her feet and then suddenly everything goes black. Suicide is the third cause of death in teens. It takes about 35,000 lives each year, almost 11 million people have tried to take their lives. Suicide can be triggered by many things, this action has many effects but can be solved with some simple steps. Suicide can be triggered by many actions. To start off with , suicide can be caused by many different feelings. Feelings of guilt, shame, anger, rejection or loss can cause suicide. According to D’Arcy Lyness from KidsHealth.org, rejection, hurting, or loss are some emotions out of many which causes suicide Guilt is also a factor which causes this act.(kidshealth.org â€Å"Suicide† By D’Arcy Lyness) Basically, if a person experiences these feelings than they want to escape these hor rible emotions than they pick the route of suicide to evade these feelings. Furthermore, suicide can be provoked by drug or substance abuse. The article â€Å"Suicide† from Kids Health Organization says that â€Å"Teens with alcohol and drug problems are also more at risk for suicidal thinking and behavior.†(kidshealth.org â€Å"Suicide† By D’Arcy Lyness) If a person does drugs or drinks alchocol then they will be more likely to be less happy. Once they take drugs their happy place changes to a new higher level.